Gene: [11^/F2] coagulation factor II (prothrombin; fibrinogenase); disprothrombinemia; hypoprothrombinemia (prothrombin);

GEN

The gene length is 21 kb. Exons: 14.

FUN

Thrombin (fibrinogenase) is a serine proteinase with limited specificity (by Arg-). It converts fibrinigen into fibrin."

FAG

On the fibrin gene cluster, see FAM:F1/04q28.

REF

GEN,SEQ,MOP "Degen SJF, Davie: Biochemistry, 26, 6165-6177, 1987
CLO,COD,SEQ,GEN "Degen SJF &: Biochemistry, 22, 2087-2097, 1983
MUT,PEP,SEQ,MEB,PAT "Henriksen RA, Mann: Biochemistry, 27, N26, 9160-9165, 1988
PRO,LOC "Royle NJ &: Somat Cell Mol Genet, 13, 285-292, 1987

SWI

 SWISSPROT: P00734

KEY

hem, clot

CLA

coding, basic

LOC

11 p11-q12

MIM

 MIM: 176930

EZN

 ENZYME: 3.4.21.5

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